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Weight Gain and Weight Loss: Does Your Body Weight Depend on Your Gut Microbiome?

Weight Gain and Weight Loss: Does Your Body Weight Depend on Your Gut Microbiome?

5-minute read · Erzsébet Soltész, dietitian

Gut microbiome: a mysterious diversity

The human microbiome is one of the most popular research topics today, and tests to explore your individual gut microbiome are becoming available in more and more places. However, these tests are still essentially snapshots that can only show the most significant deviations in your current microbiome composition compared to what is considered optimal.

The number of microorganisms inhabiting our bodies and digestive systems is almost incomprehensible, somewhere in the order of 30,000,000,000,000 to 40,000,000,000,000. Several hundred types of bacteria live as permanent co-inhabitants in each of our digestive systems, and yet we still know relatively little about the complex processes and self-regulating mechanisms of this diverse inner world.

This is what makes research into the relationship between microbiome characteristics and various health conditions so exciting. Perhaps the most fascinating area is the connection to a tendency toward obesity and unintentional weight gain. What is the vicious cycle at play?

A global obesity epidemic: it's not just about calories

In films, the pandemic that escapes from a secret lab is always stopped at the last moment. In reality, however, humanity is losing the battle against obesity. There are already more than one billion people affected worldwide, and estimates suggest that by 2035, half the world's population will be overweight.

Fat deposits around the waist and a protruding belly are typical signs of visceral fat accumulating in the abdominal cavity, which is associated with an increased risk of metabolic syndrome, including type 2 diabetes, lipid metabolism disorders, non-alcoholic fatty liver disease, and cardiovascular conditions.

Alongside excessive calorie intake and insufficient physical activity, a fiber-poor diet associated with modern lifestyles is one of the main culprits in the obesity epidemic. Inadequate intake of the fibers that nourish the gut microbiome disrupts the balance of the digestive and metabolic systems, which can result in impaired sugar and fat metabolism.

Disruption of insulin regulation can sustain the vicious cycle of weight gain even without a caloric surplus. An important finding in recent years is that a tendency toward obesity and unsuccessful weight loss show a direct correlation with the composition of the gut microbiome. So which bacterial strains matter most?

Typical microbiome composition: cause and consequence

Several large-scale studies have observed characteristic differences in the gut microbiome composition of obese individuals. The ratio of the two most dominant bacterial phyla, Firmicutes and Bacteroidetes, was found to be elevated in obese subjects compared to those of normal body weight, meaning a "dominance" of Firmicutes was characteristic. This pattern is linked to diet: a diet high in fat and added sugar and low in fiber produces precisely this shift over the long term.

A higher proportion of Firmicutes is associated with more efficient energy extraction from food, which may contribute to a tendency toward obesity. In contrast, the Bacteroidetes phylum, and in particular certain members of the Bacteroides genus, are thought by scientists to have an anti-obesity effect. In mouse studies, Bacteroides therapy successfully reduced body weight and fat tissue in obese mice, a promising result for the development of targeted microbiome therapies against obesity.

The effect also worked in reverse: when the microbiome of obese mice was transplanted into normal-weight mice with sterile digestive systems, those mice also became obese, despite no change in their diet. This experiment further confirmed that microbiome composition has a direct effect on metabolism and the tendency to gain weight. But what is the right balance?

It's not that simple: the critical balance of the Firmicutes/Bacteroidetes ratio

Based on the above, Bacteroidetes bacteria might appear to be the good guys and Firmicutes the villains. According to numerous scientific publications, a shift in the Firmicutes/Bacteroidetes ratio in the gut microbiome is associated not only with obesity but also with disorders of fat and sugar metabolism, and even with a higher risk of breast cancer.

An obvious conclusion might be: "Let's get rid of all Firmicutes bacteria, and we can forget about dieting and prevent a whole range of diseases!" As tempting as this thought is, such an extreme approach would do no good.

As in every area of life, balance is what matters in the microbiome. It is a complex microbial world in which both bacterial phyla play important roles. They interact with each other through the substances they produce, and within BOTH groups there are bacteria that regulate our energy metabolism through their anti-inflammatory effects and their influence on appetite.

The Firmicutes/Bacteroidetes ratio can also be too extreme in the other direction: an EXCESSIVE presence of the otherwise "friendly" Bacteroidetes bacteria may be associated with a higher risk of irritable bowel syndrome and inflammatory bowel disease.

What is the takeaway? Instead of extreme diets, aim for variety and moderation in your eating habits. A balanced, nutrient and fiber-rich diet does the most to support your microbiome equilibrium. But how can you avoid being prone to weight gain in the first place?

How can you support your microbiome to avoid a tendency toward weight gain?

Fortunately, the gut microbiome is remarkably flexible: the composition of your diet can influence its makeup relatively quickly and significantly. To support beneficial, probiotic bacterial strains, it is worth regularly consuming fermented vegetables and live-culture dairy products.

The macronutrient composition of your diet also matters: excessive fat and sugar consumption damages the diversity of the microbiome and can promote the growth of certain disease-causing bacteria.

The most important task is ensuring adequate intake of the dietary fibers that feed your gut bacteria. The dietary fibers that pass through the digestive system in undigested form are gladly received by the residents of your microbiome. The fibers that serve as nutrients for these bacteria are called prebiotic fibers.

The best strategy for supporting the Bacteroidetes bacteria that offer some protection against a tendency to gain weight, and for restoring a healthy balance, is varied fiber consumption. Since your body cannot store fiber, you need to ensure you consume multiple types of fiber in your diet every day.

Wonderful examples of prebiotic fibers include:

  • Inulin, found in onions, Jerusalem artichokes, and artichokes
  • Pectin, found in apples, pears, and berries
  • Beta-glucan, found in oats and barley
  • Resistant starch, found in unripe or green bananas

How to take care of your microbiome:

  • The composition of your gut microbiome is critically important alongside diet and exercise for reaching and maintaining a healthy body weight.
  • To support a diverse gut microbiome, aim for the recommended daily intake of 30 grams of fiber.
  • Take care of your prebiotic fiber intake every day by eating a wide variety of vegetables, fruits, wholegrains, seeds, and nuts.
  • Make sure you consume multiple types of fiber each day and combine different fibers to make the most of their benefits.
  • If you are short on time and use a fiber supplement, check that it contains prebiotic fiber.
  • Alongside your fiber-conscious diet, drink plenty of plain water.

 

Sources used:

Soltész E., Gajda Z. Fiber is good! Budapest: BOOOK Publisher; 2020

An, J., Kwon, H., & Kim, Y. J. (2023). The Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer. Journal of clinical medicine, 12(6), 2216.

Barna, I., Nyúl, D., Szentes, T., and Schwab, R. (2018). A review of the relationship between the gut microbiome, metabolic diseases, and hypertension. Orvosi Hetilap OH 159, 9, 346-351.

NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403(10431):1027-1050.

Ryu SW, Moon JC, Oh BS, et al. Anti-obesity activity of human gut microbiota Bacteroides stercoris KGMB02265. Arch Microbiol. 2023;206(1):19.

Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI. The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med. 2009;1(6):6ra14.